Prenatal developmental toxicity study of glycosides-based standardized fenugreek seed extract in rats
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چکیده
منابع مشابه
Prenatal Developmental Toxicity Study of Glycosides-based Standardized Fenugreek Seed Extract in Rats
CONTEXT Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. AIM The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). MATERIAL AND METHODS Mated female rats w...
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Objective: To evaluate prenatal safety of furostanol saponin glycoside based standardized fenugreek seed extract (Fenu-FG) on pregnant female Wistar rats on embryo–fetal development organogenesis period in accordance with OECD guideline (No. 414). Methods: Fenu-FG was administered to pregnant rats by gavage at 250, 500, and 1000 mg/kg/day over the exposure period of gestational days 5– 19. The ...
متن کاملPreclinical safety assessment of glycosides based standardized fenugreek seeds extract: Acute, subchronic toxicity and mutagenicity studies
Article history: Received on: 29/03/2016 Revised on: 07/07/2016 Accepted on: 08/08/2016 Available online: 26/09/2016 Objective: To evaluate acute oral toxicity (AOT), subchronic toxicity, and mutagenic potential of glycosides based standardized fenugreek (Trigonella foenum graecum L.) seeds extract (SFSE-G). Materials and Methods: The AOT, subchronic (90-day repeated dose) toxicity and mutageni...
متن کاملGlycosides Based Standardized Fenugreek Seed Extract Ameliorates Bleomycin-induced Liver Fibrosis in Rats Via Modulation of Endogenous Enzymes
BACKGROUND Liver fibrosis a complex process of excess collagen deposition resulted in disturbance of hepatic cellar function. Glycosides based standardized fenugreek seed extract (SFSE-G) has potent anti-inflammatory, antioxidant, and anti-fibrotic properties. OBJECTIVE The aim of this study is to evaluate the hepatoprotective potential of SFSE-G against bleomycin (BLM)-induced liver fibrosis...
متن کاملTherapeutic effects of standardized fenugreek seed extract on experimental urolithiasis in rats
Article history: Received on: 13/08/2013 Revised on: 05/09/2013 Accepted on: 22/09/2013 Available online: 30/09/2013 The objective of the present study was to investigate therapeutic efficacy of standardized fenugreek seed extract with trigonelline as marker (SFSE-T) in experimental urolithiasis in rats. Effects of subacute oral treatments of SFSE-T (30 and 60 mg/kg) and reference anti-urolithi...
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ژورنال
عنوان ژورنال: Pharmacognosy Magazine
سال: 2017
ISSN: 0973-1296
DOI: 10.4103/0973-1296.203978